The drama tells the story of two second year of a hard-working study genius and a cynical born surgical fellow who doesn't believe in happiness, learning the true romance of life as they met Kim Sa-bu, a geek genius doctor who was once called the hand of God.
Three years following the events of Dr. Romantic, Kim Sa-bu (Han Seok-kyu) comes to Geo-san University Hospital to recruit a general surgeon. He finds
Seo Woo-jin (Ahn Hyo-seop) a doctor with a troubled past who is ostracized by his fellow doctors and offers him the job. In the meantime, Cha Eun-jae
(Lee Sung-kyoung) is suspended after making another mistake in the operation room and has no other choice but to follow the two doctors to Dol-dam Hospital.