Suji & Uri tells the story of Jin Soo-ji, a celebrity psychiatrist who is a perfectionist. However, her life took a turn as accidents occurred back-to-back, and Chae Woo-ri, a novice doctor who placed the patient's health as the highest priority, often crashing with Soo-ji on opinions. As Soo-ji falls from her grace after several scandals, Woo-ri becomes concerned and starts helping her.